Complexity in simplicity: monogenic disorders and complex cardiomyopathies

The Complexity Beyond Monogenic Disorders

Twelve years after the identification of the molecular bases of the long-QT syndrome, it is now possible to express some considerations on the impact that genetic findings have had in the understanding of inherited arrhythmogenic diseases. Along with the excitement for the emerging data on genotype/phenotype correlation and for the development of the first recommendations for gene-specific mana...

Emerging Monogenic Complex Hyperkinetic Disorders

PURPOSE OF REVIEW Hyperkinetic movement disorders can manifest alone or as part of complex phenotypes. In the era of next-generation sequencing (NGS), the list of monogenic complex movement disorders is rapidly growing. This review will explore the main features of these newly identified conditions. RECENT FINDINGS Mutations in ADCY5 and PDE10A have been identified as important causes of chil...

Simplicity and Complexity in Contracts

Standard economic models of contract imply that contracts should be highly “complex,” by which we mean (1) rich in the expected number of payoff-relevant contingencies; (2) variable in the magnitude of payoffs contracted to flow between parties; and (3) severe in the cognitive load necessary to understand the contract. Yet most realworld contracts are simple along all three of these dimensions....

Complexity, simplicity, and epidemiology.

It should be stressed that although many phenomena are complex, 15 the concept of ‘complexity’ is more specific. Complexity is the study of complex adaptive systems. These have been defined as ‘a collection of individual agents with freedom to act in ways that are not always totally predictable, and whose actions are interconnected so that one agent’s actions changes the context for other agent...

Monogenic Phosphate Balance Disorders